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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: APP All Species: 47.88
Human Site: Y757 Identified Species: 95.76
UniProt: P05067 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P05067 NP_958817.1 770 86943 Y757 S K M Q Q N G Y E N P T Y K F
Chimpanzee Pan troglodytes Q5IS80 770 86953 Y757 S K M Q Q N G Y E N P T Y K F
Rhesus Macaque Macaca mulatta XP_001104599 750 84778 Y737 S K M Q Q N G Y E N P T Y K F
Dog Lupus familis XP_856325 785 88788 Y772 N K M Q N H G Y E N P T Y K Y
Cat Felis silvestris
Mouse Mus musculus P12023 770 86704 Y757 S K M Q Q N G Y E N P T Y K F
Rat Rattus norvegicus P08592 770 86686 Y757 S K M Q Q N G Y E N P T Y K F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_989639 751 84687 Y738 S K M Q Q N G Y E N P T Y K F
Frog Xenopus laevis NP_001082098 749 84748 Y736 T K M Q Q N G Y E N P T Y K F
Zebra Danio Brachydanio rerio NP_571639 738 83559 Y725 S K M Q Q N G Y E N P T Y K F
Tiger Blowfish Takifugu rubipres O93279 737 82838 Y724 A R M Q Q N G Y E N P T Y K F
Fruit Fly Dros. melanogaster P14599 887 98314 Y875 P N M Q I N G Y E N P T Y K Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10651 686 79416 Y674 A G M Q V N G Y E N P T Y S F
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 94.9 50.7 N.A. 96.6 96.8 N.A. N.A. 91.8 84.8 69.7 67.2 26.2 N.A. 23.6 N.A.
Protein Similarity: 100 99.8 95.7 66.7 N.A. 97.5 97.9 N.A. N.A. 94 90.9 80.5 78.9 41.5 N.A. 42.2 N.A.
P-Site Identity: 100 100 100 73.3 N.A. 100 100 N.A. N.A. 100 93.3 100 86.6 73.3 N.A. 73.3 N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 100 100 N.A. N.A. 100 100 100 100 80 N.A. 80 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 84 % F
% Gly: 0 9 0 0 0 0 100 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 75 0 0 0 0 0 0 0 0 0 0 0 92 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 100 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 9 0 0 9 92 0 0 0 100 0 0 0 0 0 % N
% Pro: 9 0 0 0 0 0 0 0 0 0 100 0 0 0 0 % P
% Gln: 0 0 0 100 75 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 59 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % S
% Thr: 9 0 0 0 0 0 0 0 0 0 0 100 0 0 0 % T
% Val: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 100 0 17 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _